A REVIEW AND ANALYSIS OF TREATMENTS FOR CHRONIC CONSTIPATION IN ADULTS

Autori

  • Yaru Zhong Wushu College of Henan University, P. R. of China
  • Darrin Sime Nkemeni Wushu College of Henan University, P. R. of China

DOI:

https://doi.org/10.46827/ejpe.v12i3.5874

Parole chiave:

chronic constipation, prescription drugs, microbiota, dietary fiber, Tai chi

Abstract

This article reviews the treatment of chronic constipation (CC) in adults, including pharmacologic therapy, microbiota therapy, conservative interventions, and tai chi. Chronic constipation, a common gastrointestinal disorder, affects patients' physical symptoms, social functioning, and psychological health, as well as increasing healthcare costs. Therapeutic measures aim to improve patient's quality of life and reduce healthcare costs. Pharmacological treatments have been investigated with drugs such as linaclotide, procalcitonin, and lubiprostone, which have shown significant results in improving patients' quality of life, weekly spontaneous bowel movement (SBM) frequency, and chronic idiopathic constipation (CIC) symptoms. Microbiota therapies, including fecal microbiota transplantation (FMT), probiotics, prebiotics, and synbiotics, have shown positive results in increasing bowel frequency and improving stool consistency. For conservative interventions, dietary fiber and abdominal massage are the two main interventions. Dietary fiber has good efficacy in chronic constipation, and abdominal massage can significantly increase the frequency of bowel movements and improve constipation-related symptoms. Tai chi, as a gentle form of exercise, has also been shown to promote intestinal peristalsis, relieve constipation symptoms, and improve patients' quality of life.

 

Article visualizations:

Hit counter

Biografie autore

  • Yaru Zhong, Wushu College of Henan University, P. R. of China

    Yaru Zhong, Wushu College of Henan University, People’s Republic of China.

  • Darrin Sime Nkemeni, Wushu College of Henan University, P. R. of China

    Darrin Sime Nkemeni, Wushu College of Henan University, People’s Republic of China.

    Research interests in Sport Health, Sport education and Biotechnique.

    ORCID: https://orcid.org/0000-0003-4268-8846

    Email: simedarrin@yahoo.fr

Riferimenti bibliografici

Werth BL, Williams KA, Fisher MJ, Pont LG. Defining constipation to estimate its prevalence in the community: results from a national survey. bmc Gastroenterol. 2019;19(1):75.

Bharucha AE, Lacy BE. Mechanisms, Evaluation, and Management of Chronic Constipation. Gastroenterology. 2020;158(5):1232-49.e3.

Belsey J, Greenfield S, Candy D, Geraint M. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther. 2010;31(9):938-49.

Remes-Troche JM, Coss-Adame E, Lopéz-Colombo A, Amieva-Balmori M, Carmona Sánchez R, Charúa Guindic L, et al. Consenso mexicano sobre estreñimiento cr ónico. revista de Gastroenterología de México. 2018;83(2):168-89.

Gwee KA, Ghoshal UC, Gonlachanvit S, Chua AS, Myung SJ, Rajindrajith S, et al. Primary Care Management of Chronic Constipation in Asia: The ANMA Chronic Constipation Tool. J Neurogastroenterol Motil. 2013;19(2):149-60.

Esra Bozkurt M, Erdogan T, Fetullahoglu Z, Ozkok S, Kilic C, Bahat G, et al. Investigation of the prevalence of functional constipation and its related factors for in older outpatients. Acta Gastroenterol Belg. 2024;87(3):361-5.

Jeong E, Kim JA, Kim BS, Lee CK, Kim M, Won CW. Functional Constipation and Anorexia in Community-Dwelling Older Adults: Korean Frailty and Aging Cohort Study (KFACS). Int J Environ Res Public Health. 2021;18(11).

Luk-In S, Leepiyasakulchai C, Saelee C, Keeratichamroen A, Srisangwan N, Ponprachanuvut P, et al. Impact of resistant starch type 3 on fecal microbiota and stool frequency in Thai adults with chronic constipation randomized clinical trial. Scientific Reports. 2024;14(1).

Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Rev Gastroenterol Hepatol. 2020;14(1):39-46.

Yoshihara T, Kessoku T, Takatsu T, Misawa N, Ashikari K, Fuyuki A, et al. Efficacy and safety of linaclotide in treatment-resistant chronic constipation: a multicenter, open-label study. Neuro gastroenterology and motility. 2024;36(12).

Ballou S, Rangan V, Eidelberg A, Proctor S, McHenry N, Nee J, et al. What Is Unspecified Functional Bowel Disorder? A Commonly Seen, Rarely Recognized, and Poorly Understood Diagnosis. Am J Gastroenterol. 2023;118(8):1402-9.

Barberio B, Judge C, Savarino EV, Ford AC. The global prevalence of functional constipation according to the Rome criteria: a systematic review and meta- analysis. Lancet Gastroenterol Hepatol. 2021;6(8):638-48.

Sperber AD, Bangdiwala SI, Drossman DA, Ghoshal UC, Simren M, Tack J, et al. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders. Results of Rome Foundation Global Study. Gastroenterology. 2021;160(1):99-114.e3.

Bharucha AE, Wald A. Chronic Constipation. Mayo Clinic Proceedings. 2019;94(11):2340-57.

Nag A, Martin SA, Mladsi D, Olayinka-Amao O, Purser M, Vekaria RM. The Humanistic and Economic Burden of Chronic Idiopathic Constipation in the USA: A Systematic Literature Review. Clin Exp Gastroenterol. 2020;13:255-65.

Cash, B. D., Lu, M., Lembo, A., Feuerstadt, P., Nguyen, L., Terasawa, E., ... & Moshiree, B. A real-world study of persistence and adherence to prescription medications in patients with chronic idiopathic constipation in the United States. Journal of Managed Care & Specialty Pharmacy, 2024;30(10), 1136-1148.

Rao SS, Manabe N, Karasawa Y, Hasebe Y, Nozawa K, Nakajima A, et al. Comparative profiles of lubiprostone, linaclotide, and elobixibat for chronic constipation: a systematic literature review with meta- analysis and number needed to treat/harm. bmc gastroenterology. 2024;24(1).

Lembo A, Cash BD, Lu M, Terasawa E, Terreri B, Du S, et al. Clinical Outcomes Before and After Prucalopride Treatment: an Observational Study in Patients With Chronic Idiopathic Constipation in the United States. Clinical and transitional gastroenterology. 2024;15(5).

Coss-Adame E, Remes-Troche JM, Flores Rendon R, Tamayo de la Cuesta JL, Valdovinos Diaz MA. Efficacy and safety of lubiprostone for the treatment of chronic idiopathic constipation: a phase 3, randomized, placebo-controlled study. rev Gastroenterol Mex (Engl Ed). 2024;89(1):70-9.

Lee JW, Kim N. Efficacy of Fecal Microbial Transplantation for Improving Symptoms of Irritable Bowel Syndrome- A Pilot Study for Voluntary Participants in Korea. KOREAN JOURNAL OF GASTROENTEROLOGY. 2024;84(4):168-76.

Deng X, Liang C, Zhou L, Shang X, Hui X, Hou L, et al. Network meta-analysis of probiotics, prebiotics, and synbiotics for the treatment of chronic constipation in adults. European Journal of Nutrition. 2024;63(6):1999-2010.

Terrén Lora, A., Penadés, B. F., López Oliva, S., Arponen, S., Okutan, G., Sánchez Niño, G. M., & San Mauro Martín, I. (2024). Supplementation with probiotics, prebiotics, and synbiotics in patients with chronic functional constipation: a randomized, double-blind, placebo-controlled pilot clinical trial. Gastroenterology Report, 12, goae101.

Garzon Mora N, Jaramillo AP. Effectiveness of Probiotics in Patients With Constipation: a Systematic Review and Meta-Analysis. cureus. 2024;16(1):. e52013.

Kwon H, Nam EH, Kim H, Jo H, Bang WY, Lee M, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. sci Rep. 2024;14(1):22384.

Abdalla SA, Al-Mana NM, Hasosah SM, Alghamdi NM, Alkhamesi AA. Effects of Dietary Fiber Intake and the Prevalence of Constipation Among Patients With End -Stage Renal Disease (ESRD) in Jeddah, Saudi Arabia: a Cross-Sectional Observational Study. cureus. 2024;16(6):e62289.

van der Schoot A, Katsirma Z, Whelan K, Dimidi E. Systematic review and meta-analysis: foods, drinks and diets and their effect on chronic constipation in adults. Aliment Pharm Ther. 2024;59(2):157-74.

Huang SY, Chiao CY, Chien LY. Effectiveness of abdominal massage on chronic constipation in adults: a systematic review and meta-analysis. Int J Nurs. Stud. 2025;161:104936.

van der Schoot A, Helander C, Whelan K, Dimidi E. Probiotics and synbiotics in chronic constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2022;41(12):2759-77.

Zhang C, Jiang J, Tian F, Zhao J, Zhang H, Zhai Q, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020;39(10):2960-9.

Sutherland P, Hallett II, Redgwell R, Benhamou N, MacRae E. Localization of Cell Wall Polysaccharides during Kiwifruit (Actinidia deliciosa) Ripening. Int J Plant Sci. 1999;160(6):1099-109.

Dawson DM, Melton LD. Two pectic polysaccharides from kiwifruit cell walls. Carbohydrate Polymers. 1991;15(1):1-11.

Redgwell RJ, Melton LD, Brasch DJ. Cell-wall polysaccharides of kiwifruit (Actinidia deliciosa): chemical features in different tissue zones of the fruit at harvest. Carbohydrate Research. 1988;182(2):241-58.

Wilkinson-Smith V, Dellschaft N, Ansell J, Hoad C, Marciani L, Gowland P, et al. Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers. Aliment Pharm Ther. 2019;49(6):759-68.

Goya-Jorge E, Bondue P, Gonza I, Laforêt F, Antoine C, Boutaleb S, et al. Butyrogenic, bifidogenic, and slight anti-inflammatory effects of a green kiwifruit powder (Kiwi FFG®) in a human gastrointestinal model simulating mild constipation. Food Res Int. 2023;173(Pt 2):113348.

Zou, L., Pan, Z., Yeung, A., Talwar, S., Wang, C., Liu, Y., ... & Thomas, G. A. A review study on the beneficial effects of Baduanjin. J. Altern. Complement. Med., 2018;24(4), 324-335.

Kang, D., Wang, X., & Wang, J. Intervention study of tai chi training on the intestinal flora of college student basketball players. Medicine, 2023;102(36), e35044.

Cui, L., Zhao, T., Hu, H., Zhang, W., & Hua, X. Association study of gut flora in coronary heart disease through high‐throughput sequencing. BioMed research international, 2017(1), 3796359.

Kang D, Wang X, Wang J. Intervention study of Tai Chi training on the intestinal flora of college student basketball players. Medicine (Baltimore). 2023;102(36):e35044.

Dowloads

Pubblicato

2025-03-10

Fascicolo

V. 12 N. 3 (2025)

Sezione

Articles

Licenza

Authors who publish with this journal agree to the following terms:

 

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

 

  1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

 

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).