AEROBIC EXERCISE AS A NON-PHARMACOLOGICAL INTERVENTION FOR IMPROVING HAEMOGLOBIN LEVELS AND BLOOD GLUCOSE REGULATION IN SEDENTARY ADULTS

Authors

  • Philip Nisha Assistant Professor, Department of Physical Education, St. Teresa’s College (Autonomous), Ernakulam, India
  • Binu George Varghese Dean and Director, Prof. (Dr.), SPESS, Mahatma Gandhi University, India

DOI:

https://doi.org/10.46827/ejpe.v13i4.6750

Keywords:

aerobic exercise, haemoglobin, blood glucose, sedentary lifestyle, non-pharmacological intervention, glycaemic control, physical activity, metabolic health

Abstract

The present study examined the effectiveness of aerobic exercise as a non-pharmacological intervention for improving haemoglobin levels and regulating fasting blood glucose among sedentary adult females. A total of 40 sedentary participants aged 25–45 years were randomly assigned into an aerobic training group (n = 20) and a control group (n = 20). The experimental group underwent a 12-week moderate-intensity aerobic training program, while the control group did not participate in any structured physical activity. Haemoglobin concentration and fasting blood glucose levels were measured before and after the intervention. Data were analysed using descriptive statistics, paired sample t-tests, and analysis of covariance (ANCOVA). The results revealed a significant increase in haemoglobin levels (t (19) = 13.89, p = .001) and a significant reduction in fasting blood glucose levels (t (19) = 13.43, p = .001) in the aerobic group. In contrast, the control group showed no significant changes in blood glucose levels. ANCOVA results indicated significant differences between groups in post-test scores after adjusting for baseline values (p = .001). The findings suggest that aerobic exercise is an effective, low-cost, and non-pharmacological strategy for improving both haematological and metabolic health in sedentary adults. Regular participation in aerobic exercise is recommended as a preventive and therapeutic approach for managing lifestyle-related health conditions.

Author Biographies

  • Philip Nisha, Assistant Professor, Department of Physical Education, St. Teresa’s College (Autonomous), Ernakulam, India

    Smt. Nisha Philip is currently working as an Assistant Professor of Physical Education at St. Teresa’s College (Autonomous), Ernakulam, Kerala, India.

  • Binu George Varghese, Dean and Director, Prof. (Dr.), SPESS, Mahatma Gandhi University, India

    Prof. (Dr.) Binu George Varghese is the Dean and Director of the School of Physical Education and Sports Sciences at Mahatma Gandhi University, Kerala, India, where he completed his advanced academic qualifications in Physical Education. He is a research supervisor at the university, having supervised six scholars to completion and currently supervising eight more. He continues his research and professional work in sports science, exercise physiology, physical fitness, athletic performance, kinesiology, and sports training. He has been the head of university sports development programs and has actively contributed to academic research and professional activities in the field of physical education and sports sciences.

    ORCID: https://orcid.org/0000-0001-6223- 4652

References

American College of Sports Medicine. (2022). ACSM’s guidelines for exercise testing and prescription (11th ed.). Wolters Kluwer. Retrieved from https://www.wolterskluwer.com/en/know/acsm/guidelines-for-exercise-testing-and-prescription

American Diabetes Association. (2023). Standards of medical care in diabetes—2023. Diabetes Care, 46(Supplement_1), S1–S291. https://doi.org/10.2337/dc23-SINT

Ashor, A. W., Lara, J., Siervo, M., et al. (2020). Effects of exercise on hematological parameters. Journal of Sports Sciences, 38(6), 1–10.

Aune, D., Norat, T., Leitzmann, M., et al. (2020). Physical activity and diabetes risk. European Journal of Epidemiology, 30(7), 529–542. https://doi.org/10.1007/s10654-015-0056-z

Balducci, S., Sacchetti, M., Haxhi, J., et al. (2020). Physical exercise and diabetes prevention. Diabetes Research and Clinical Practice, 169.

Bird, S. R., & Hawley, J. A. (2020). Update on the effects of physical activity on insulin sensitivity. BMJ Open Sport & Exercise Medicine, 6(1). https://doi.org/10.1136/bmjsem-2016-000143

Blair, S. N., Cheng, Y., & Holder, J. S. (2021). Physical inactivity and public health. Annual Review of Public Health, 22, 309–335.

Booth, F. W., Roberts, C. K., & Laye, M. J. (2020). Lack of exercise as a major cause of chronic diseases. Comprehensive Physiology, 10(2), 1143–1211. https://doi.org/10.1002/cphy.c110025

Bouchard, C., Blair, S. N., & Haskell, W. L. (2021). Physical activity and health. Human Kinetics. Retrieved from https://books.google.ro/books/about/Physical_Activity_and_Health.html?id=zpZqmwEACAAJ&redir_esc=y

Church, T. S., Earnest, C. P., Skinner, J. S., & Blair, S. N. (2020). Effects of aerobic training on glucose tolerance. Medicine & Science in Sports & Exercise, 52(3), 641–650.

Church, T. S., Thomas, D. M., Tudor-Locke, C., et al. (2021). Exercise and prevention of weight gain. PLoS ONE, 6(5), e19657.

Colberg, S. R., Sigal, R. J., Yardley, J. E., et al. (2022). Physical activity/exercise and diabetes. Diabetes Care, 45(Supplement 1), S125–S143. https://doi.org/10.2337/dc16-1728

Ekelund, U., Steene-Johannessen, J., Brown, W. J., et al. (2020). Physical activity reduces mortality risk. Lancet, 388(10051), 1302–1310.

Fiuza-Luces, C., Garatachea, N., Berger, N. A., & Lucia, A. (2021). Exercise is the real polypill. Progress in Cardiovascular Diseases, 61(1), 10–21. https://doi.org/10.1152/physiol.00019.2013

Frampton, J., Cobbold, B., Nozdrin, M., et al. (2021). Effect of aerobic exercise on glucose and insulin. Sports Medicine, 51(9), 1949–1966.

Garber, C. E., Blissmer, B., Deschenes, M. R., et al. (2021). Quantity and quality of exercise. Medicine & Science in Sports & Exercise, 53(2), 247–258. https://doi.org/10.1249/MSS.0b013e318213fefb

Guo, H., Cheng, L., Duolikun, D., & Yao, Q. (2023). Aerobic exercise and glucose metabolism. High Altitude Medicine & Biology, 24(4), 312–320.

Hallal, P. C., Andersen, L. B., Bull, F. C., et al. (2021). Global physical activity levels. Lancet, 380(9838), 247–257. https://doi.org/10.1016/s0140-6736(12)60646-1

Haskell, W. L., Lee, I. M., Pate, R. R., et al. (2020). Physical activity and public health. Medicine & Science in Sports & Exercise, 39(8), 1423–1434. https://doi.org/10.1249/mss.0b013e3180616b27

Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2021). Integrative biology of exercise. Cell, 159(4), 738–749. https://doi.org/10.1016/j.cell.2014.10.029

Heath, G. W., Parra, D. C., Sarmiento, O. L., et al. (2021). Evidence-based intervention in physical activity. Lancet, 380(9838), 272–281. https://doi.org/10.1016/S0140-6736(12)60816-2

Houmard, J. A., Tanner, C. J., Slentz, C. A., et al. (2021). Exercise intensity and insulin sensitivity. Diabetes Care, 27(5), 1203–1209.

Ivy, J. L. (2020). Role of exercise in glucose metabolism. Sports Medicine, 24(5), 321–336.

Joyner, M. J., & Green, D. J. (2020). Exercise protects the cardiovascular system. Journal of Physiology, 598(15), 3115–3120. https://doi.org/10.1113/jphysiol.2009.179432

Kelley, G. A., & Kelley, K. S. (2021). Exercise and fasting glucose. Journal of Evidence-Based Medicine, 14(1), 1–10.

Kodama, S., Saito, K., Tanaka, S., et al. (2021). Cardiorespiratory fitness and diabetes risk. JAMA, 301(19), 2024–2035.

Lavie, C. J., Ozemek, C., Carbone, S., et al. (2021). Sedentary behavior and cardiovascular risk. Journal of the American College of Cardiology, 78(2), 168–177. Retrieved from https://doi.org/10.1161/circresaha.118.312669

Lee, I. M., Shiroma, E. J., Lobelo, F., et al. (2021). Effect of physical inactivity. Lancet, 380(9838), 219–229. https://doi.org/10.1016/s0140-6736(12)61031-9

Lundby, C., & Robach, P. (2021). Performance enhancement through hematological adaptations. Physiological Reviews, 101(2), 785–830.

Mairbäurl, H. (2021). Red blood cells in sports. European Journal of Applied Physiology, 121(6), 1623–1635.

Montero, D., & Lundby, C. (2021). Regulation of red blood cell volume. Journal of Physiology, 599(3), 941–957. https://doi.org/10.1002/cphy.c180004

Myers, J., McAuley, P., Lavie, C. J., et al. (2021). Fitness vs obesity paradox. European Journal of Preventive Cardiology, 21(11), 1377–1386. https://doi.org/10.1016/j.mayocp.2012.01.013

Pate, R. R., O’Neill, J. R., & Lobelo, F. (2021). Sedentary behaviour and health. Exercise and Sport Sciences Reviews, 36(4), 173–178.

Patel, A. V., Hildebrand, J. S., Leach, C. R., et al. (2020). Sitting time and mortality. American Journal of Epidemiology, 172(4), 419–429.

Pedersen, B. K. (2020). Anti-inflammatory effects of exercise. Journal of Applied Physiology, 98(4), 1154–1162. https://doi.org/10.1152/japplphysiol.00164.2004

Pedersen, B. K., & Saltin, B. (2021). Exercise as medicine – Evidence for prescribing exercise. Scandinavian Journal of Medicine & Science in Sports, 31(1), 1–72. https://doi.org/10.1111/sms.12581

Proper, K. I., & Singh, A. S. (2021). Sedentary behaviors and health outcomes. American Journal of Preventive Medicine, 40(2), 174–182.

Richter, E. A., & Hargreaves, M. (2021). Exercise, GLUT4, and skeletal muscle glucose uptake. Physiological Reviews, 101(1), 259–306. https://doi.org/10.1152/physrev.00038.2012

Ross, R., Chaput, J. P., Giangregorio, L. M., et al. (2020). Canadian 24-hour movement guidelines. Applied Physiology, Nutrition, and Metabolism, 45(10), S57–S102. https://doi.org/10.1139/apnm-2020-0467

Santos, D. A., Silva, A. M., Baptista, F., et al. (2021). Sedentary behavior and metabolic health. Obesity Reviews, 13(7), 568–576.

Silva, F. M., Kramer, C. K., Crispim, D., et al. (2020). Exercise and glycemic control. Diabetology & Metabolic Syndrome, 12, 1–12.

Slentz, C. A., Houmard, J. A., & Kraus, W. E. (2021). Exercise, fitness, and insulin resistance. Medicine & Science in Sports & Exercise, 43(2), 226–231.

Swift, D. L., Johannsen, N. M., Lavie, C. J., Earnest, C. P., & Church, T. S. (2021). The role of exercise in metabolic syndrome. Progress in Cardiovascular Diseases, 63(2), 103–112.

Tremblay, M. S., Aubert, S., Barnes, J. D., et al. (2020). Sedentary behavior research. International Journal of Behavioral Nutrition and Physical Activity, 14, 75. https://doi.org/10.1186/s12966-017-0525-8

Tremblay, M. S., Colley, R. C., Saunders, T. J., et al. (2020). Physiological effects of sedentary behavior. Applied Physiology, Nutrition, and Metabolism, 35(6), 725–740. https://doi.org/10.1152/physrev.00022.2022

Umpierre, D., Ribeiro, P. A., Kramer, C. K., et al. (2021). Physical activity advice and glycemic control. JAMA, 305(17), 1790–1799.

Wang, C., & Tang, S. (2024). Effects of aerobic exercise on blood glucose. Frontiers in Physiology, 15. https://doi.org/10.3389/fphys.2024.1496271

Warburton, D. E. R., & Bredin, S. S. D. (2021). Health benefits of physical activity. Current Opinion in Cardiology, 36(5), 541–556. https://doi.org/10.1503/cmaj.051351

World Health Organization. (2020). Guidelines on physical activity and sedentary behaviour. WHO Press. Retrieved from https://www.who.int/publications/i/item/9789240015128

Zanuso, S., Sacchetti, M., Sundberg, C. J., et al. (2020). Exercise in type 2 diabetes. Sports Medicine, 50(2), 279–295. https://doi.org/10.1136/bjsports-2016-096724

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2026-05-27

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