CHRONIC DISEASES AND KETOGENIC DIET – AN OVERVIEW
Abstract
The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet. Normally, the carbohydrates contained in food are transformed into glucose, which is then transported around the body. The low carbohydrates intake forces the body to burn fats rather than carbohydrates. The ketogenic diet has been shown to generate beneficial metabolic changes in the short-term. Along with weight loss, health parameters associated with carrying excess weight have improved, such as insulin resistance, high blood pressure, and elevated cholesterol and triglycerides.
References
Bruci, A.; Tuccinardi, D.; Tozzi, R.; Balena, A.; Santucci, S.; Frontani, R.; Mariani, S.; Basciani, S.; Spera, G.; Gnessi, L.; Lubrano, C.; Watanabe, M. Very Low-Calorie Ketogenic Diet: A Safe and Effective Tool for Weight Loss in Patients with Obesity and Mild Kidney Failure. Nutrients 2020, 12, 333.
Castellana, M., Conte, E., Cignarelli, A. et al. Efficacy and safety of very low-calorie ketogenic diet (VLCKD) in patients with overweight and obesity: A systematic review and meta-analysis. Rev Endocr Metab Disord (2019). https://doi.org/10.1007/s11154-019-09514-y.
Davis, J. J., Fournakis, N., & Ellison, J. (2020). Ketogenic Diet for the Treatment and Prevention of Dementia: A Review. Journal of Geriatric Psychiatry and Neurology. https://doi.org/10.1177/0891988720901785.
Di Lorenzo, C.; Pinto, A.; Ienca, R.; Coppola, G.; Sirianni, G.; Di Lorenzo, G.; Parisi, V.; Serrao, M.; Spagnoli, A.; Vestri, A.; Schoenen, J.; Donini, L.M.; Pierelli, F. A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones? Nutrients 2019, 11, 1742.
Diet Review: Ketogenic Diet for Weight Loss. (2019, May 22). Retrieved from https://www.hsph.harvard.edu/nutritionsource/healthy-weight/diet-reviews/ketogenic-diet/.
Elizabeth G. Neal, Hannah Chaffe, Ruby H. Schwartz, Margaret S. Lawson, Nicole Edwards, Georgianna Fitzsimmons, Andrea Whitney, J. Helen Cross (2008). The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. The Lancet Neurology, Jun;7(6):500-6. doi: 10.1016/S1474-4422(08)70092-9.
Frank Lefevre and Naomi Aronson (2000). Ketogenic Diet for the Treatment of Refractory Epilepsy in Children: A Systematic Review of Efficacy. Pediatrics April 2000, 105 (4) e46; DOI: https://doi.org/10.1542/peds.105.4.e46.
Gordon, B. (n.d.). What is the Ketogenic Diet. Retrieved from https://www.eatright.org/health/weight-loss/fad-diets/what-is-the-ketogenic-diet
Hayden White, Balasubramanian Venkatesh, Mark Jones, Peter S. Kruger, James Walsham & Hesly Fuentes (2020). Inducing ketogenesis via an enteral formulation in patients with acute brain injury: a phase II study, Neurological Research, DOI: 10.1080/01616412.2019.1709743.
J. Williams Mackenzie, C. Cervenka (2017). The role for ketogenic diets in epilepsy and status epilepticus in adults. Clinical Neurophysiology Practice, Volume 2, 2017, Pages 154-160.
Keene, Daniel L. (2006). A Systematic Review of the Use of the Ketogenic Diet in Childhood Epilepsy, Pediatric Neurology, Volume 35, Issue 1, 1 – 5.
Ketogenic diet. (2020, March 12). Retrieved from https://en.wikipedia.org/wiki/Ketogenic_diet.
Kuchkuntla, A.R., Shah, M., Velapati, S. et al. Ketogenic Diet: an Endocrinologist Perspective. Curr Nutr Rep 8, 402–410 (2019). https://doi.org/10.1007/s13668-019-00297-x.
Løkken, N, Hansen, KK, Storgaard, JH, Ørngreen, MC, Quinlivan, R, Vissing, J. Titrating a modified ketogenic diet for patients with McArdle disease: A pilot study. J Inherit Metab Dis. 2020; 1– 9. https://doi.org/10.1002/jimd.12223.
Paoli, A., Mancin, L., Giacona, M.C. et al. Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. J Transl Med 18, 104 (2020). https://doi.org/10.1186/s12967-020-02277-0.
Phenytoin. (2020, February 6). Retrieved from https://en.wikipedia.org/wiki/Phenytoin.
The Ketogenic Diet: Pros and Cons According to NUNM. (2019, August 12). Retrieved from https://nunm.edu/2019/02/ketogenic-diet/.
Valenzano, A.; Polito, R.; Trimigno, V.; Di Palma, A.; Moscatelli, F.; Corso, G.; Sessa, F.; Salerno, M.; Montana, A.; Di Nunno, N.; Astuto, M.; Daniele, A.; Carotenuto, M.; Messina, G.; Cibelli, G.; Monda, V. Effects of Very Low Calorie Ketogenic Diet on the Orexinergic System, Visceral Adipose Tissue, and ROS Production. Antioxidants 2019, 8, 643. https://doi.org/10.3390/antiox8120643.
Valproate. (2020, March 4). Retrieved from https://en.wikipedia.org/wiki/Valproate.
Włodarek, D. (2019). Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease). Nutrients 2019, 11, 169.
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