HISTORICAL DEVELOPMENT OF VACCINES AND PUBLIC RESISTANCE: THE IMPACT OF COVID-19 PANDEMIC ON VACCINE HESITANCY AMONG ARABS IN ISRAEL
DOI:
https://doi.org/10.46827/ejphs.v9i2.264Keywords:
vaccine hesitancy, COVID-19, Arabs in Israel, mixed-methods research, Health Belief Model, Theory of Planned Behavior, public health communication, trustAbstract
Background: Vaccine hesitancy continues to be a pressing public health challenge worldwide. Changes in public trust in vaccines have intensified since the COVID-19 pandemic, most acutely in the case of ethnic minorities, which stresses the need for elucidating the socio-cultural, institutional and cognitive drivers of vaccine behavior. Methods: This study was developed using an explanatory sequential mixed-methods design to examine vaccine hesitancy among Arabs in Israel. In the quantitative component of this research (200 participants), the study examined the influence of the Health Belief Model (HBM) constructs, the Theory of Planned Behavior (TPB) components, trust in science, and religious fatalism and social support, using multiple linear regression analysis. In the qualitative component, semi-structured interviews with 20 purposively selected participants were performed and analyzed using thematic analysis. Both methods' results were integrated via the explanatory sequential approach. Results: The regression model explained 65.3% of the variance in vaccine hesitancy (R² = 0.653). Attitude toward vaccination emerged as the strongest negative predictor (β = −0.376, p < 0.001), followed by trust in science (β = −0.278, p < 0.001), while perceived barriers (β = 0.300, p < 0.001) and religious fatalism (β = 0.162, p < 0.001) significantly increased vaccine hesitancy. Social support demonstrated a modest protective effect (β = −0.120, p = 0.014). Qualitative findings revealed that vaccine hesitancy reflected a process of critical evaluation rather than outright rejection, characterized by concerns regarding rapid vaccine development, institutional transparency, misinformation, and cultural influences. Participants expressed greater trust in healthcare professionals than in governmental institutions and emphasized the importance of culturally sensitive communication. Conclusions: Vaccine hesitancy among Arabs in Israel should not be understood as a simple distinction between acceptance and refusal. Rather, it reflects a dynamic decision-making process shaped by perceived barriers, attitudes toward vaccination, trust in science, religious interpretation, social support, and broader sociocultural and institutional contexts. Public health strategies should therefore move beyond standard educational messages and prioritize transparent risk communication, culturally tailored interventions, partnerships with trusted healthcare professionals and community leaders, and sustained efforts to strengthen institutional trust.
References
Ajzen, I. (2020). The theory of planned behavior: Frequently asked questions. Human Behavior and Emerging Technologies, 2(4), 314–324. https://doi.org/10.1002/hbe2.195
Andre, F. E., Booy, R., Bock, H. L., Clemens, J., Datta, S. K., John, T. J., Lee, B. W., Lolekha, S., Peltola, H., Ruff, T. A., Santosham, M., & Schmitt, H. J. (2008). Vaccination greatly reduces disease, disability, death and inequity worldwide. Bulletin of the World Health Organization, 86(2), 140–146. https://doi.org/10.2471/BLT.07.040089
Anuar, H., Shah, S. A., Gafor, H., Mahmood, M. I., & Ghazi, H. F. (2020). Usage of Health Belief Model (HBM) in health behavior: A systematic review. Malaysian Journal of Medicine and Health Sciences, 16(Suppl. 11), 201–209. Retrieved from https://www.researchgate.net/publication/347558135_Usage_of_Health_Belief_Model_HBM_in_Health_Behavior_A_Systematic_Review
Bar, E., Lerman, Y., & Muhsen, K. (2021). Factors influencing the acceptance of COVID-19 vaccines among minority populations in Israel. Israel Medical Association Journal, 23, 285–290.
Bell, J., Lartey, B., Spickernell, G., Darrell, N., Salt, F., Gardner, C., Richards, E., Fasakin, L., Egbeniyi, S., Odongo, E., Ssenkungu, J., Kouadio, R. K., Cissé, M., Rérambyah, A. B. A. I., Adou, M., West, R., & Sharma, S. (2022). Applying a social-ecological model to understand factors impacting demand for childhood vaccinations in Nigeria, Uganda, and Guinea. SSM - Qualitative Research in Health, 2, 100180. https://doi.org/10.1016/j.ssmqr.2022.100180
Blank, R. (2023). Influenza prevention in Israel, with emphasis on vaccination among adults aged 65 and older. Knesset Research and Information Center.
Bussink-Voorend, D. M., Hautvast, J. L. A., Vandeberg, L., Visser, O., & Hulscher, M. E. J. L. (2022). A systematic literature review to clarify the concept of vaccine hesitancy. Nature Human Behaviour, 6(12), 1634–1648. https://doi.org/10.1038/s41562-022-01431-6
Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3(2), 77–101. https://doi.org/10.1191/1478088706qp063oa
Centers for Disease Control and Prevention. (2020b). Vaccine safety information. https://www.cdc.gov/vaccine-safety/index.html
Chait, R. M., Nastiti, A., Chintana, D. A., Sari, P. N., Marasabessy, N., Firdaus, M. I., Dirgawati, M., Agustian, D., West, H., Ariesyady, H. D., & Shibata, T. (2024). Using the social–ecological model to assess vaccine hesitancy and refusal in a highly religious lower-middle-income country. International Journal of Environmental Research and Public Health, 21(10), 1335. https://doi.org/10.3390/ijerph21101335
Chapman, S., Christodoulaki, M. E., Davey, S. A., & Gaffiero, D. (2026). Understanding vaccine hesitancy: The role of fear and message framing in COVID-19 vaccination intention in adults in the UK. Vaccine, 69. https://doi.org/10.1016/j.vaccine.2025.127999
Christodoulakis, A., Bouloukaki, I., Aravantinou-Karlatou, A., Zografakis-Sfakianakis, M., & Tsiligianni, I. (2024). Vaccine hesitancy and associated factors amongst health professionals: A scoping review of the published literature. Vaccines, 12(12), 1411. https://doi.org/10.3390/vaccines12121411
Creswell, J. W., & Plano Clark, V. L. (2018). Designing and conducting mixed methods research (3rd ed.). SAGE Publications. Retrieved from https://collegepublishing.sagepub.com/products/designing-and-conducting-mixed-methods-research-3-241842
Dopelt, K., Yukter, S., Shmukler, T., & Abudin, A. (2024). Vaccine hesitancy against influenza among students and its association with vaccination history, knowledge, attitudes, and trust in the healthcare system. Social Issues in Israel, 33(2), 409–444.
Dubé, E., Laberge, C., Guay, M., Bramadat, P., Roy, R., & Bettinger, J. A. (2013). Vaccine hesitancy: An overview. Human Vaccines & Immunotherapeutics, 9(8), 1763–1773. https://doi.org/10.4161/hv.24657
Faye, S. L. B., Krumkamp, R., Doumbia, S., Tounkara, M., Strauss, R., Ouedraogo, H. G., Sagna, T., Barry, A. M., Mbawah, A. K., Doumbia, C. O., Diouf, S., Cisse, K., Harding, M., Donven, P., May, J., Puradiredja, D. I., Fusco, D., & ACHES Consortium. (2022). Factors influencing hesitancy towards adult and child COVID-19 vaccines in rural and urban West Africa: A cross-sectional study. BMJ Open, 12(4). https://doi.org/10.1136/bmjopen-2021-059138
Grills, L. A., & Wagner, A. L. (2023). The impact of the COVID-19 pandemic on parental vaccine hesitancy: A cross-sectional survey. Vaccine, 41(41), 6127–6133. https://doi.org/10.1016/j.vaccine.2023.08.044
Halperin, D., Schor, A., Eizenberg-Mashiach, M., Karpati, T., Sprecher, E., & Friedman, N. (2020). Intentions to receive the COVID-19 vaccine among the elderly population in Israel: The role of trust, risk perception, and social norms. Gerontology & Geriatrics, 47(3–4), 163–188.
Israel Center for Disease Control. (2018). Development of vaccination programs in Israel (1918–2010).
Kumar, S., Quinn, S. C., Kim, K. H., Musa, D., Hilyard, K. M., & Freimuth, V. S. (2012). The social ecological model as a framework for determinants of 2009 H1N1 influenza vaccine uptake in the United States. Health Education & Behavior, 39(2), 229–243. https://doi.org/10.1177/1090198111415105
Okumuş, H., Ghorbani, S., & Karatepe, S. (2019). A study on relationship between financial performance and supply chain in the accepted companies in Borsa Istanbul. Uncertain Supply Chain Management, 7(3), 417-426. https://doi.org/10.5267/j.uscm.2018.12.005
Rosenstock, I. M., Strecher, V. J., & Becker, M. H. (1988). Social learning theory and the Health Belief Model. Health Education Quarterly, 15(2), 175–183. https://doi.org/10.1177/109019818801500203
Taflinger, S., & Sattler, S. (2024). A situational test of the Health Belief Model: How perceived susceptibility mediates the effects of the environment on behavioral intentions. Social Science & Medicine, 346, 116715. https://doi.org/10.1016/j.socscimed.2024.116715
Thompson, S., Meyer, J. C., Burnett, R. J., & Campbell, S. M. (2023). Mitigating vaccine hesitancy and building trust to prevent future measles outbreaks in England. Vaccines, 11(2), 288. https://doi.org/10.3390/vaccines11020288
Tregoning, J. S., Flight, K. E., Higham, S. L., Wang, Z., & Pierce, B. F. (2021). Progress of the COVID-19 vaccine effort: Viruses, vaccines and variants versus efficacy, effectiveness and escape. Nature Reviews Immunology, 21(10), 626–636. https://doi.org/10.1038/s41577-021-00592-1
Widyaningsih, S. A., & Hakim, M. S. (2024). COVID-19 pandemic and its impact on vaccine hesitancy: A review. Oman Medical Journal, 39(4). https://doi.org/10.5001/omj.2024.103
World Health Organization. (2014). Report of the SAGE Working Group on Vaccine Hesitancy. https://cdn.who.int/media/docs/default-source/immunization/sage/2014/october/sage-working-group-revised-report-vaccine-hesitancy.pdf
World Health Organization. (2019). Ten threats to global health in 2019. https://www.who.int/news-room/spotlight/ten-threats-to-global-health-in-2019
Yan, Y., Pang, Y., Lyu, Z., Wang, R., Wu, X., You, C., Zhao, H., Manickam, S., Lester, E., Wu, T., & Pang, C. H. (2021). The COVID-19 vaccines: Recent development, challenges and prospects. Vaccines, 9(4), 349. https://doi.org/10.3390/vaccines9040349
Yılmaz, M., Durmaz, A., & Arıkan, İ. (2026). The effect of the COVID-19 pandemic on vaccines and vaccination-related beliefs in Türkiye: A cross-sectional study. African Journal of Reproductive Health, 30(1), 116–123. https://doi.org/10.29063/ajrh2026/v30i1.13
Zewdie, A., Mose, A., Sahle, T., Bedewi, J., Gashu, M., Kebede, N., & Yimer, A. (2022). The Health Belief Model’s ability to predict COVID-19 preventive behavior: A systematic review. SAGE Open Medicine, 10. https://doi.org/10.1177/20503121221113668
Zhang, Z., Shen, Q., & Chang, H. (2022). Vaccines for COVID-19: A systematic review of immunogenicity, current development, and future prospects. Frontiers in Immunology, 13, 843928. https://doi.org/10.3389/fimmu.2022.843928
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